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Literature summary extracted from

  • Li, Y.; Li, Y.; Feng, Q.; Arnold, M.; Peng, T.
    Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes (2009), Cardiovasc. Res., 84, 100-110.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.22.52 medicine calpain-1 activation is important in the development of diabetic cardiomyopathy and thus represents a potential therapeutic target for diabetic heart diseases Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.52 calpain inhibitor-III
-
 Rattus norvegicus
3.4.22.52 calpastatin
-
 Rattus norvegicus
3.4.22.52 PD150606
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.52 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.52 cardiomyocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.52 N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O
-
 Rattus norvegicus N-succinyl-LLVY + 7-amino-4-methylcoumarin
-
 ?

Expression

EC Number Organism Comment Expression
3.4.22.52 Rattus norvegicus high glucose (33 mM) induces calpain-1 activation in cardiomyocytes. Gp91phox-NADPH oxidase contributes to calpain-1 activation in high glucose-induced cardiomyocytes up

General Information

EC Number General Information Comment Organism
3.4.22.52 physiological function calpain-1 activation induces apoptosis through down-regulation of the Na+/K+ ATPase activity in high glucose-stimulated cardiomyocytes and in vivo hyperglycaemic hearts. High glucose-induced calpain-1 activation is mediated through the NADPH oxidase-dependent pathway and associated with activation of L-type calcium channels and ryanodine receptors Rattus norvegicus